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Modelling and simulation of array microneedle by consideration of insertion mechanism of mosquito’s proboscis / Mohd Norzaidi Mat Nawi

Modelling and simulation of array microneedle by consideration of insertion mechanism of mosquito’s proboscis_Mohd Norzaidi Mat Nawi_E3_2010_875003549_00003084239_NI
Projek ini bertujuan untuk merekabentuk dan mensimulasikan microneedle dengan menggunakan perisian Microelectromechanical systems (MEMS). Ia menunjukkan analisis tentang in-plane Microneedle silikon yang digunakan untuk mengambil sampel darah dalam aplikasi biomedik. Ciri-ciri in-plane microneedle didapati lebih berkesan daripada out-of-plane microneedle bagi tujuan pengambilan sampel darah. Dalam projek ini, CoventorWare digunakan untuk merekabentuk in-plane Microneedle. Bermula daripada proses sehingga bentangan dua dimensi (2D) dan juga tiga dimensi (3D). Untuk pengesahan, model 3-D dibina, dan disimulasi menggunakan penyelesai penganalisis. Berdasarkan beberapa dimensi microneedle yang telah diselidik dan telah dioptimum menggunakan analisis mekanikal, Microneedle sepanjang 3mm telah digunakan untuk projek ini. Kekuatan microneedle telah dianalisis secara analitikal dan dimodel menggunakan alat permodelan elemen terhad. Selain itu, aliran bendalir juga dianalisis secara analitikal dan dimodel menggunakan alat permodelan isipadu terhad. Untuk tujuan ini, satu microchannel bergaris pusat 20μm digunakan. Kemudian, dengan meneliti belalai nyamuk, microneedle dibina dengan satu jarum lurus dan dua jarum luar yang bergerigi, dan keberkesanan jarum itu dari segi sisipannya telah diselidik secara teori. _________________________________________________________________________________________ The objective of this project is to design and simulate a microneedle by using Microelectromechanical systems (MEMS) software. It presents the analysis for the in-plane silicon microneedles that can be used for blood sampling for biomedical applications. The characteristics of in-plane microneedles are far more reliable than out-of-plane microneedles for blood sampling. In this project, in-plane microneedle was designed by using CoventorWare. From the process until two dimension layout (2D) and also three dimension (3D). For verification, a 3-D model was built, meshed and simulated using the Analyzer solvers. Several needle dimensions were investigated, and the microneedle shape was optimized using mechanical strength analysis. A 3mm long microneedle was used for this project. The strength of the microneedles has been examined analytically and modeled using finite element modelling tools. In addition, fluid also has been examined analytically and modelled using finite volume method tools. For this purposes, 20μm diameter of microchannel was used. Then, by imitating the mosquito’s proboscis, the combined microneedles comprising a central straight needle and two outer jagged needles have been already proposed, and th
Contributor(s):
Mohd Norzaidi Mat Nawi - Author
Primary Item Type:
Final Year Project
Identifiers:
Accession Number : 875003549
Language:
English
Subject Keywords:
microneedle; blood sampling; mosquito’s proboscis,
First presented to the public:
4/1/2010
Original Publication Date:
8/2/2018
Previously Published By:
Universiti Sains Malaysia
Place Of Publication:
School of Electrical & Electronic Engineering
Citation:
Extents:
Number of Pages - 89
License Grantor / Date Granted:
  / ( View License )
Date Deposited
2018-08-02 16:05:31.199
Date Last Updated
2019-01-07 11:24:32.9118
Submitter:
Nor Hayati Ismail

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Modelling and simulation of array microneedle by consideration of insertion mechanism of mosquito’s proboscis / Mohd Norzaidi Mat Nawi1 2018-08-02 16:05:31.199