Meningkatkan bioavalibility curcumin boleh diperbaiki dengan mengurangkan saiz zarah curcumin. Bagi tujuan ini, kaedah gabungan solvent antisolvent telah digunakan ke atas sifat fizikal zarah curcumin telah dikaji. Tambahan pula, kebolehlarutan curcumin beku kering yang diperolehi dari kombinasi solvent antisolvent cenderung untuk menjadi lebih larut daripada curcumin komersial Dari imej mikroskop imbasan elektron, ia telah ditentukan bahawa zarah curcumin boleh dikurangkan sehingga 340 nm. Saiz zarah direkodkan daripada gabungan curcumin + etanol + air. Saiz zarah hampir 500 nm lebih kecil daripada curcumin komersial yang 880 nm. Selain itu, berdasarkan proses pemendapan, diketahui bahawa kestabilan curcumin + etanol + air adalah lebih stabil berbanding dengan curcumin + metanol + air dan curcumin + aseton + air. Di samping itu, kajian FTIR mendedahkan bahawa penyediaan zarah curcumin melalui kaedah solvent dan antisolvent membawa kepada peningkatan kelarutan dan pengurangan saiz zarah. Berbeza kajian imbasan kalorimeter mencadangkan penghabluran lebih rendah zarah curcumin direka dalam kajian ini. Oleh itu, kajian ini menunjukkan bahawa gabungan solvent antisolvent pada curcumin adalah faktor penting yang perlu dipertimbangkan apabila mengurangkan lebih kecil zarah bersaiz curcumin dari curcumin komersial. Selain daripada itu, persediaan eksperimen yang mudah digunakan dalam kajian ini menunjukkan potensi yang baik untuk digunakan untuk penyediaan curcumin nanopartikel.
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Improving the bioavalibility of curcumin can be improved by reducing the particle size of curcumin. For this purpose, solvent antisolvent combination method has been utilized on the physical properties of curcumin particles were studied. Furthermore, the solubility of the freeze dried curcumin obtained from solvent antisolvent combinations tend s to be more soluble than the commercial curcumin From the scanning electron microscope images, it was determined that the curcumin particle can be reduced up to 340 nm. The particle size was recorded from the combination of curcumin + ethanol + water. The particle size was almost 500 nm smaller than commercial curcumin which was 880 nm. Moreover, based on the sedimentation process, it is known that the curcumin + ethanol + water is more stable compared to curcumin + methanol + water and curcumin + acetone + water combination. In addition, study of FTIR revealed that the preparation of curcumin particles via solvent and antisolvent method led to enhanced in solubility and reduction of particle size. Differential scanning calorimetry studies suggested lower crystallinity of curcumin particles fabricated in this study. Therefore, this study demonstrated that solvent antisolvent combination on curcumin is an important factor that should be considered when fabricating smaller sized curcumin particle from commercial curcumin. Other than that, the simple experimental setup used in this study showed good potential to be used for the preparation of curcumin nanoparticle.
A study on the effect of solvent types on the physical characteristics of curcumin particles / Barataraj Buskaran